Nasal administration of a rescue treatment for severe hypoglycemia
Nasal delivery of glucagon
BAQSIMI is absorbed passively through the mucosal membrane of the nose3,4
The nasal mucosa is highly penetrable due to its large surface area and rich vascularization5,6
Lipophilic drugs like nasal glucagon are well absorbed from the nasal cavity3,4
When BAQSIMI permeates the nasal mucosa, it is distributed into the bloodstream
How all formations of glucagon work
Glucagon binds to and activates hepatic glucagon receptors
This stimulates glycogen breakdown and release of glucose from the liver3
This in turn produces an antihypoglycemic effect3
SELECT IMPORTANT SAFETY INFORMATION
Most common (≥10%) adverse reactions associated with BAQSIMI are nausea, vomiting, headache, upper respiratory tract irritation (i.e., rhinorrhea, nasal discomfort, nasal congestion, cough, and epistaxis), watery eyes, redness of eyes, and itchy nose, throat and eyes.
Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given BAQSIMI. In patients taking indomethacin, BAQSIMI may lose its ability to raise blood glucose or may even produce hypoglycemia. BAQSIMI may increase the anticoagulant effect of warfarin.